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Biochemistry
New biochemistry study findings have been reported by researchers at Okayama University
April 16th, 2007
Scientists discuss in "Rapid hematopoietic progenitor mobilization by sulfated colominic acid" new findings in biochemistry. "Hematopoietic progenitor cells (HPCs) can be mobilized from bone marrow (BM) to the blood by G-CSF. In this process, CXCR4 and CD26 play critical roles," scientists in Okayama, Japan report. "Sulfated colominic acid (SCA) inhibits HIV entry, the step which requires CXCR4 and CD26 as co-receptors. Thus, we hypothesized that SCA would modulate HPC trafficking. We first found that SCA mobilized HPCs rapidly via CD26-independent mechanism. In vitro progenitor migration toward chemokine SDF-1 was significantly enhanced by SCA, and it was completely...
Source: Hematology Week (2007-04-16)
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