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Fanconi Anemia
Researchers from University Autonoma of Barcelona detail findings in fanconi anemia
April 16th, 2007
New research, "Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability," is the subject of a report. According to recent research from Barcelona, Spain, "Fanconi anemia (FA) is a chromosome fragility syndrome characterized by bone marrow failure and cancer susceptibility. The central FA protein FANCD2 is known to relocate to chromatin upon DNA damage in a poorly understood process." "Here, we have induced subnuclear accumulation of DNA damage to prove that histone H2AX is a novel component of the FA/BRCA pathway in response to stalled replication forks. Analyses of cells from H2AX knockout mice or expressing a...
Source: Hematology Week (2007-04-16)
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