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Hematopoietic
Research conducted at University of Salamanca has updated our knowledge about hematopoietic
April 16th, 2007
New investigation results, "Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice," are detailed in a study published in Molecular Biology of the Cell. "The Vav family is a group of signal transduction molecules that activate Rho/Rac GTPases during cell signaling. Experiments using knockout mice have indicated that the three Vav proteins present in mammals (Vav1, Vav2, and Vav3) are essential for proper signaling responses in hematopoietic cells," researchers in Salamanca, Spain report. "However, Vav2 and Vav3 are also highly expressed in nonhematopoietic tissues, suggesting that they may have additional functions outside blood cells....
Source: Hematology Week (2007-04-16)
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