Sickle Cell Anemia Therapy
Research on sickle cell anemia therapy reported by scientists at INSERM
Published in Hematology Week, May 21st, 2007
New research, "Sodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: relevance to sickle-cell disease," is the subject of a report. According to a study from Paris, France, "As hydroxyurea (HU), sodium phenyl butyrate (SPB) is known to induce fetal hemoglobin (HbF) expression and thus shows potentials for sickle-cell disease (SCD) treatment. More recently, few studies suggested that endothelial cells (ECs), a major pathophysiological actor of SCD, are also a target of SPB."
"Here, we show that SPB, as HU, reduces endothelin-1 mRNA expression and peptide release by human ECs in culture. SPB increases VCAM-1 and ICAM-1 mRNAs and...
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Source: Hematology Week (2007-05-21)
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