Burkitt Lymphoma
Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
Published in Hematology Week, June 18th, 2007
Endemic Burkitt lymphoma is a form of cancer that accounts for up to 74% of malignant disorders in children in equatorial Africa. Malaria and Epstein-Barr virus (EBV) are known cofactors in its development, but to date, their relative contribution has not been well understood. In a new study published online in the open-access journal PLoS Pathogens, researchers at the Karolinska Institutet in Stockholm explain how certain Plasmodium falciparum antigens directly induce Epstein-Barr virus (EBV) reactivation, increasing the risk of Burkitt lymphoma.
EBV is a ubiquitous virus that establishes a lifelong persistence following primary infection. How EBV affects its host...
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Source: Hematology Week (2007-06-18)
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