Gene Therapy

Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

Published in Hematology Week, August 20th, 2007

Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.

The findings may point researchers to future gene therapies for patients with sickle cell anemia and beta-thalassemia.

In an article pre-published online Aug. 3 as a First Edition Paper in the journal Blood, the journal of the American Association for Hematology, researchers reported that a protein called KLF2 coordinates with a related and...

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Source: Hematology Week (2007-08-20)

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