Leukemia Genetics

Scientists at University of Texas, M.D. Anderson Cancer Center target leukemia genetics

Published in Hematology Week, October 15th, 2007

Data detailed in 'C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL' have been presented. According to a study from the United States, "Translocations involving the mixed-lineage leukemia gene (MLL) confer a poor prognosis in acute leukemias. In t(1;11)(q21;q23), MLL is fused reciprocally with AF1q."

"Here we describe a t(1;11)(q21;q23) with a secondary event involving insertion of the telomeric portion of MLL into the p arm of chromosome 11 (11p11). We show that this latter event interrupts the CUG triplet repeat binding protein-1 (CUGBP1) gene, a translational enhancer of C/EBPbeta. We then showed that these cells have...

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Source: Hematology Week (2007-10-15)

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