Published in Hematology Week, February 4th, 2008
"Eight hundred and seventeen samples were studied prospectively for Pgp protein expression and function and G1199A, G2677T and C3435T polymorphisms in the encoding geneABCB1. Age, lowWBC count, high bcl-2, secondaryAML and myelodysplastic syndrome, and adverse cytogenetics all correlated strongly with high Pgp (MRK16) protein expression. However, ABC131 3435TT homozygosity was negatively correlated with Pgp. Pgp...
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