Acute Myeloid Leukemia

Researchers from City Hospital detail new studies and findings in the area of acute myeloid leukemia

Published in Hematology Week, February 4th, 2008

According to recent research from Nottingham, the United Kingdom, "P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid leukemia (AML). This study compared the influence of genetic and leukemia-specific factors on Pgp."

"Eight hundred and seventeen samples were studied prospectively for Pgp protein expression and function and G1199A, G2677T and C3435T polymorphisms in the encoding geneABCB1. Age, lowWBC count, high bcl-2, secondaryAML and myelodysplastic syndrome, and adverse cytogenetics all correlated strongly with high Pgp (MRK16) protein expression. However, ABC131 3435TT homozygosity was negatively correlated with Pgp. Pgp...

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Source: Hematology Week (2008-02-04)

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