Acute Promyelocytic Leukemia

New acute promyelocytic leukemia study results from University of Sao Paulo described

Published in Hematology Week, February 4th, 2008

According to a study from Ribeirao Preto, Brazil, "Background and Objectives Differentiation Syndrome (DS) is a treatment complication which can occur in patients treated with acute promyelocytic leukemia (APL) with all trans-retinoic acid (ATRA) or AS(2)O(3), and is characterized by enhanced leukocyte transmigration. AS(2)O(3), Phenylbutyrate (PB) and G-CSF are known to potentiate ATRA effects."

"Our aim was to analyze the changes in expression and function of adhesion molecules induced by ATRA, AS(2)O(3), G-CSF and PB, and their association. Design and Methods APL blasts and NB4 cells were treated with ATRA, AS(2)O(3), PB, G-CSF or their association and the expression...

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Source: Hematology Week (2008-02-04)

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