Renal Hypertension

Research reports from G. Salguero and co-authors provide new insights into renal hypertension

Published in Hematology Week, March 24th, 2008

" Enhanced mechanical forces, e. g. in arterial hypertension, stimulate the formation of reactive oxygen species (ROS)by the NAD(P)H oxidase. Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates EPC mobilization in a NAD(P)H oxidase-dependent manner," researchers in Hannover, Germany report.

" Renovascular hypertension was induced by two-kidney one-clip (2K1C) in C57BL/6 (WT) and in mice lacking the p47(phox) subunit of the NAD(P)H oxidase (p47phox(-/-)). In WT, 2K1C increased blood pressure levels by 32.4 +/- 4 mmHg, which was associated with a four-fold...

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Source: Hematology Week (2008-03-24)

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