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Sepsis

Research from University of Michigan broadens understanding of sepsis

Published in Hematology Week, March 31st, 2008

Investigators publish new data in the report 'Role of the complement in experimental sepsis.' "At the Trauma, Shock, Inflammation and Sepsis 2007 conference, the roles of complement activation products and relevant receptors were stressed in the setting of experimental sepsis [cecal ligation and puncture (CLP)] in mice and rats. In addition, some limited evidence was presented related to humans with septic shock (requiring vasopressor support)," scientists in the United States report.

"Collectively, the data suggested that events found in CLP also occur in human sepsis. Experimental sepsis (CLP) in rodents is associated with robust complement consumption and appearance...

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