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Alpha-thalassemia
Report summarizes alpha-thalassemia study findings from Mahidol University
May 12th, 2008
"beta-Thalassemia/Hb E patients show a range of clinical severities, from nearly asymptomatic to transfusion-dependent thalassemia major. This study investigated the clinical heterogeneity and hematologic parameters obtained in the large cohort of 925 Thai beta(0)-thalassemia/Hb E patients," scientists in Thailand report. "Coinheritance of alpha-thalassemia with beta(0)-thalassemia/Hb E produces a milder clinical phenotype in contrast to an interaction of alpha-globin gene triplication in severe thalassemia. The mean steady-state Hb was also higher, whereas the mean corpuscular volume and the percentage of Hb F were markedly lower in the former group," wrote O. Sripichai...
Source: Hematology Week (2008-05-12)
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