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Sickle Cell Anemia

Reports outline sickle cell anemia study results from A.A. Canalli et al

Published in Hematology Week, May 26th, 2008

"Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell disease. Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseaseneu). sickle cell diseaseneu presented greater adhesion in vitro to both fibronectin and ICAM-1 than control neutrophils," investigators in Campinas, Brazil report.

"Co-incubation of sickle cell diseaseneu with the nitric oxide-donor agents, sodium nitroprusside and clietheylamine...

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