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Gene Therapy

Data on gene therapy published by researchers at University of Glasgow

Published in Hematology Week, May 26th, 2008

New investigation results, 'GADD34 gene restores virulence in viral vector used in experimental stroke study,' are detailed in a study published in Journal of Cerebral Blood Flow and Metabolism. According to recent research from Glasgow, the United Kingdom, "GADD34 is expressed in the ischaemic brain and reverses protein synthesis shutdown. Consequently, GADD34 could have neuroprotective potential in stroke."

"BHK medium, a replication-deficient HSV viral vector (HSV1716) with no insert or containing full-length GADD34, the N terminal or a conserved portion of the gene, was injected into mouse brain before stroke. Infarct size was 1.0±0.26,...

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