Sepsis

Research from M. Pahuja and co-researchers provides new data on sepsis

Published in Hematology Week, July 21st, 2008

"Macrophage dysfunction occurs late in sepsis,and is implicated in increased mortality. Interferon gamma (IFN-gamma) stimulates transmigration of high mobility group box 1 (HMGB-1) from the nucleus into cytoplasm of macrophages and subsequent release," scientists in the United States report.

"Because HMGB-1 release also occurs late, and because one of the actions of HMGB-1 in the nucleus is to enhance transcription factors, we investigated if HMGB-1 transmigration is involved in macrophage suppression in sepsis. Alveolar macrophages were isolated 12 and 24 h from sham controls, cecal ligation and puncture (CLIP), and CILP rats given IFN-gamma antibody (1.2 mg/kg, i.v.)....

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Source: Hematology Week (2008-07-21)

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