Published in Hematology Week, July 21st, 2008
"Because HMGB-1 release also occurs late, and because one of the actions of HMGB-1 in the nucleus is to enhance transcription factors, we investigated if HMGB-1 transmigration is involved in macrophage suppression in sepsis. Alveolar macrophages were isolated 12 and 24 h from sham controls, cecal ligation and puncture (CLIP), and CILP rats given IFN-gamma antibody (1.2 mg/kg, i.v.)....
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