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Angiogenesis

Scientists at University of Lubeck target angiogenesis

Published in Hematology Week, July 21st, 2008

"The goal of this study was to determine the contribution of bone marrow-derived circulating endothelial progenitor cells to the formation of endothelial cell linings of tumor vessel walls. The proportion of male endothelial cells in female JC and WEHI tumors was measured in male BALB/c mice and in female mice displaying complete marrow chimerism, after receiving male bone marrow cells," scientists in Lubeck, Germany report.

"The gender origin of the perivascular endothelial cells was determined by fluorescent in situ hybridization (FISH) analysis of adjacent cuts of the tumors, using CD31 and Y-chromosomes as markers. High proportions of male cells were detected in the...

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