Kidneys

Research from Georgetown University in kidneys provides new insights

Published in Hematology Week, July 28th, 2008

"Renal tubule epithelial cells express the insulin receptor (IR); however, their value has not been firmly established. We generated mice with renal epithelial cell-specific knockout of the IR by Cre-recombinase-IoxP recombination using a kidney-specific (Ksp) cadherin promoter," scientists in the United States report.

"KO mice expressed significantly lower levels of IR mRNA and protein in kidney cortex (49-56% of the WT) and medulla (32-47%) homogenates. Immunofluorescence showed the greatest relative reduction in the thick ascending limb and collecting duct cell types. Body weight, kidney weight, and food and water intakes were not different from WT littermates....

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Source: Hematology Week (2008-07-28)

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