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Diabetes Animal Studies

University of California, Department of Pathology details research in diabetes animal studies

Published in Hematology Week, August 18th, 2008

Data detailed in 'Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide' have been presented. "Prosaposin is both a precursor of sphingolipid activator proteins and a secreted neurotrophic and myelinotrophic factor. Because peripheral nerve regeneration is impaired in diabetes mellitus, we measured prosaposin protein levels from control and streptozotocin-diabetic rats by collecting endoneurial fluid secreted into a bridging tube connecting the ends of transected sciatic nerve," scientists in the United States report.

"Prosaposin protein levels were significantly reduced in...

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