Perfusion

Researchers from University of Birmingham, Medical Department describe findings in perfusion

Published in Hematology Week, October 27th, 2008

"Exposure of endothelial cells (EC) to shear stress reduces their response to tumour necrosis factor-a (TNF). We tested how shear-conditioned EC responded to reduction in flow, either by spontaneously binding leukocytes, or by increasing sensitivity to TNF," investigators in Birmingham, the United Kingdom report.

"Human umbilical vein EC were exposed to shear stress of 2.0 Pa (20 dyn/cm(2)) for 24 h. Shear was then reduced to stasis (30 sec perfusion each hour to exchange medium) or 0.003 Pa (creeping flow). At chosen times, neutrophils were perfused over the EC at 0.1 Pa (effective reperfusion). EC developed an ability to capture flowing neutrophils that lasted from 1...

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Source: Hematology Week (2008-10-27)

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