Published in Hematology Week, December 29th, 2008
"Under hypoxic conditions, HIF stabilization leads to enhanced transcription and regulation of a multitude of processes, including erythropoiesis. Herein, we examine the biochemical characterization of PHD2 variants, Arg371His and Pro317Arg, identified from patients with familial erythrocytosis," wrote M.B. Pappalardi and colleagues, GlaxoSmithKline, Collegeville.
The researchers concluded:...
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