Diabetes Animal Studies
New diabetes animal studies study findings recently were published by M.L. Martinez and co-researchers
Published in Hematology Week, December 29th, 2008
Research findings, 'Lercanidipine decreases vascular matrix metalloproteinase-2 activity and protects against vascular dysfunction in diabetic rats,' are discussed in a new report. "Abnormal matrix metalloproteinases (MMPs) activity causes cardiovascular diseases. Because hyperglycemia increase MMPs activities through increased oxidative stress, we hypothesized that antioxidant effects produced by lercanidipine could attenuate the increases in MMP-2 expression/activity in diabetic rats," scientists writing in the European Journal of Pharmacology report.
"Control and diabetic (alloxan-induced diabetes) rats received lercanidipine 2.5 mg/kg/day (or tap water)...
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Source: Hematology Week (2008-12-29)
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