Hematology
Studies in the area of hematology reported from Kyoto University
Published in Hematology Week, January 19th, 2009
According to a study from Kyoto, Japan, "We demonstrate that lck promoter-driven conditional expression of transgenic SPA-1, a Rap GTPase-activation protein, causes a profound defect of alpha beta T-cell development at the CD4/CD8 double-negative (DN) stage due to enhanced cell death without affecting gamma delta T-cell development. The effect was specific to the DN stage, because CD4 promoter-driven SPA-1 expression hardly affected T-cell development."
"Rap1A17, a dominant-negative Rap mutant, interfered with the generation of double-positive (DP) cells from Rag2(-/-) fetal thymocytes in vitro in the presence of anti-CD3 epsilon antibody and Notch ligand. Rap GTPases...
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Source: Hematology Week (2009-01-19)
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