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Johns Hopkins Medical Institutions

Viagra's other talents: Help a 'signaling' protein shield the heart from high blood pressure damage

Published in Hematology Week, January 19th, 2009

Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein.

The team's findings, to be published in the Journal of Clinical Investigation online Jan. 5, helps explain why sildenafil, more widely known as Viagra, has already been shown to improve heart function and may one day have value in either treating or preventing heart damage due to chronic high blood pressure.

The key, investigators say, is sildenafil's effects on a single protein, RGS2, newly identified in the latest study as an essential link in...

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