Chronic Lymphocytic Leukemia

Data from R. Vangent and colleagues advance knowledge in chronic lymphocytic leukemia

Published in Hematology Week, February 9th, 2009

"Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this also applies to patients with stable disease. In this study (H2O)-H-2 was administered to a clinically homogeneous cohort of nine stable, untreated CLL patients," investigators in Netherlands report.

"CLL dynamics in blood and bone marrow were determined and compared with normal B-cell dynamics in blood from five healthy individuals who underwent a similar (H2O)-H-2 labeling protocol. Average CLL turnover rates (0.08-0.35% of the clone per day) were similar to 2-fold lower than average B-cell turnover rates from...

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Source: Hematology Week (2009-02-09)

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