"Integrins are the major adhesion receptors of leukocytes and platelets. beta(1) and beta(2) integrin function on leukocytes is crucial for a successful immune response and the platelet integrin alpha(IIb)beta(3) initiates the process of blood clotting through binding fibrinogen(1-3). Integrins on circulating cells bind poorly to their ligands but become active after 'inside-out' signaling through other membrane receptors(4,5)," scientists in London, the United Kingdom report.
"Subjects with leukocyte adhesion deficiency-1 (LAD-I) do not express beta(2) integrins because of mutations in the gene specifying the beta(2) subunit, and they suffer recurrent bacterial...
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