Thrombasthenia
New thrombasthenia study findings have been published by L. Svensson and colleagues
Published in Hematology Week, April 20th, 2009
"Integrins are the major adhesion receptors of leukocytes and platelets. beta(1) and beta(2) integrin function on leukocytes is crucial for a successful immune response and the platelet integrin alpha(IIb)beta(3) initiates the process of blood clotting through binding fibrinogen(1-3). Integrins on circulating cells bind poorly to their ligands but become active after 'inside-out' signaling through other membrane receptors(4,5)," scientists in London, the United Kingdom report.
"Subjects with leukocyte adhesion deficiency-1 (LAD-I) do not express beta(2) integrins because of mutations in the gene specifying the beta(2) subunit, and they suffer recurrent bacterial...
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Source: Hematology Week (2009-04-20)
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