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BloodCenter of Wisconsin

BloodCenter of Wisconsin’s New Genetic Test Identifies People at High Risk for Developing Inherited Form of Leukemia

Published in Hematology Week, July 6th, 2009

BloodCenter of Wisconsin's Diagnostic Laboratories announced that it is the first laboratory in the United States to develop and offer a genetic test, known as "CEBPA Mutation Analysis," for inherited acute myeloid leukemia (AML). AML is the second most common form of leukemia.

The link between inherited variants in the CEBPA gene and the familial form of acute myeloid leukemia (AML) was first described in the New England Journal of Medicine in 2004. This relationship has subsequently been confirmed in several published reports. Almost all patients found to have inherited CEBPA mutations have had leukemia. Therefore, germline CEBPA mutations appear to predict the...

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