Cancer

Research from National Cancer Institute has provided new data on cancer

Published in Hematology Week, July 6th, 2009

According to a study from the United States, "P-glycoprotein (Pgp) antagonists have had unpredictable pharmacokinetic interactions requiring reductions of chemotherapy. We report a phase I study using tariquidar (XR9576), a potent Pgp antagonist, in combination with vinorelbine."

"Patients first received tariquidar alone to assess effects on the accumulation of Tc-99m-sestamibi in tumor and normal organs and rhodamine efflux from CD56+ mononuclear cells. In the first cycle, vinorelbine pharmacokinetics was monitored after the day 1 and 8 doses without or with tariquidar. In subsequent cycles, vinorelbine was administered with tariquidar. Tariquidar pharmacokinetics was...

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Source: Hematology Week (2009-07-06)

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