Gene Therapy

New findings from T.M. Liu and co-authors in the area of gene therapy published

Published in Hematology Week, October 19th, 2009

According to a study from Singapore, Singapore, "Mesenchymal stem cells (MSCs) represent a source of pluripotent cells that are already in various phases of clinical application. However, the use of MSCs in tissue engineering has been hampered largely due to their limitations, including low proliferation, finite life span, and gradual loss of their stem cell properties during ex vivo expansion."

"Nanog and Oct4 are key transcription factors essential to the pluripotent and self-renewing phenotypes of undifferentiated embryonic stem cells (ESCs). To determine whether Nanog and Oct4 improve human bone marrow-MSC quality, we therefore established stable Nanog and Oct4...

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Source: Hematology Week (2009-10-19)

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