Cord Blood

Studies from L.C.J. Vandenberk and colleagues reveal new findings on cord blood

Published in Hematology Week, March 22nd, 2010

"Recently, the antagonizing effect on the differentiation of mesenchymal stem cells (MSCs) by toll-like receptor (TLR) ligands, was described. Our study shows that on more primitive cord blood derived MSCs, the expression of TLRs and ligand-induced triggering differs from that of bone marrow derived MSCs," scientists in Netherlands report.

"At the RNA level, cord blood MSCs (unrestricted somatic stem cells; USSCs) express low levels of TLR1,3,5,9 and high levels of TLR4 and TLR6. At the protein level expression of TLR5 and very low expression of TLR4 was observed. NF-kappa B translocation studies revealed that both TLR4 and TLR5 are functional, although signalling...

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Source: Hematology Week (2010-03-22)

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