Leukemia

Findings from A. Chiaretti et al in Leukemia Reported

Published in Hematology Week, December 5th, 2011

2011 DEC 5 -- According to the authors of a study from Rome, Italy, "Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury."

"To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression...

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Source: Hematology Week (2011-12-05)

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