Transfusion Medicine
Findings from Massachusetts Institute of Technology Broaden Understanding of Transfusion Medicine
Published in Hematology Week, April 9th, 2012
2012 APR 9 -- "A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report additional structure activity relationship (SAR) studies that delineate the requirements for activity at PAR1 and identify plasma-stable analogues with nanomolar inhibition of PAR1-mediated platelet activation," scientists writing in the journal ACS Medicinal Chemistry Letters report.
"Compound 4 was declared as a probe (ML161) with the NIH Molecular Libraries Program....
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Source: Hematology Week (2012-04-09)
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