"Complete Nucleotide Sequences and the Characteristics of Two Hepatitis B Virus Mutants Causing Serologically Negative Acute or Chronic Hepatitis B."

According to the authors' abstract of an article published in Journal of Medical Virology, "Hepatitis B virus (HBV) DNA was amplified by the polymerase chain reaction from the sera of a patient with acute hepatitis and a patient with chronic hepatitis. Both patients were negative for serum hepatitis B surface antigen and hepatitis B core antibodies and had been previously diagnosed as non-A, non-B, non-C, non-D, non-E hepatitis. The nucleotide sequence revealed an 8-nucleotide deletion in the X-gene coding region creating a C-terminally truncatedxprotein, and probable mutation of the enhancer II/core promoter element. In addition, DR2 showed a T-to-C mutation at the extreme 5'-terminus....

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