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Hepatocellular Carcinoma - Liver Cell Dysplasia

"Liver Cell Dysplasia is a Major Risk Factor for Hepatocellular Carcinoma in Cirrhosis: A Prospective Study."

Published in Hepatitis Weekly, April 17th, 1995

According to the authors' abstract of an article published in Gastroenterology, "Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of alpha-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients...

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