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Virology - Overview

"Variants of Hepatitis B, C and D Viruses: Molecular Biology and Clinical Significance."

Published in Hepatitis Weekly, April 24th, 1995

According to the author's abstract of an article published in Digestion, "Variants of hepatitis B virus (HBV), hepatitis C virus (HCV) and of the hepatitis Delta virus (HDV) have been identified in patients both with acute and chronic infections. In the HBV DNA genome, naturally occurring mutations have been found in all viral genes, most notably in the genes coding for the structural envelope and nucleocapsid proteins. In the HCV RNA genome, the regions coding for the structural envelope proteins 1 and 2 as well as the 3'-contiguous nonstructural region 1 were found to be hypervariable. Viral variants may be associated with a specific clinical course of the infection, e.g....

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