Immunology/MHC

Genetic Factors May Play Role in Persistent HBV Infection

Published in Hepatitis Weekly, May 22nd, 1995

Researchers reported finding an association between a major histocompatibility complex (MHC) II allele and protection against persistent hepatitis B infection, a condition that predisposes individuals to chronic liver disease and hepatocellular carcinoma.

The outcome of hepatitis B virus (HBV) does not seem to be determined to variations in virulence among viral strains, and the course of infection may be influenced by the host immune response, stated Mark R. Thursz, St. Mary's Hospital Medical School, London, United Kingdom, and colleagues ("Association Between an MHC Class II Allele and Clearance of Hepatitis B Virus in The Gambia," the New England Journal of...

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Source: Hepatitis Weekly (1995-05-22)

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