Treatment

Late Hepatitis Due to Pyrazinamide Carries Bad Prognosis

Published in Hepatitis Weekly, May 22nd, 1995

Subfulminant hepatitis occurring 15 days or more after the initiation of tuberculosis (TB) therapy including pyrazinamide has a bad prognosis and patients who exhibit this complication may require liver transplantation.

Isoniazid and pyrazinamide are well-known hepatotoxic drugs, often used in combination.

"The influence of combined isoniazid and pyrazinamide use on the outcome of patients developing fulminant or subfulminant liver failure is not known," researcher Francois Durand and colleagues wrote ("Deleterious Influence of Pyrazinamide on the Outcome of Patients with Fulminant or Subfulminant Liver Failure during Antituberculous Treatment...

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Source: Hepatitis Weekly (1995-05-22)

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