Virology/HBV

Fulminant Reactivation Caused by Envelope Protein Mutant

Published in Hepatitis Weekly, July 3rd, 1995

Researchers reported a fatal case involving a hepatitis B virus (HBV) mutant that was undetected by a monoclonal-antibody-based ELISA.

Hepatitis B was reactivated in a previously vaccinated Indonesian patient who had been treated by chemotherapy for lymphoma, stated W.F. Carman, University of Glasgow, Glasgow, United Kingdom, and colleagues ("Fulminant Reactivation of Hepatitis B Due to Envelope Protein Mutant That Escaped Detection by Monoclonal HBsAg ELISA," the Lancet, June 3, 1995;345:1406-1407).

Carman et al. stated that detection of the virus was delayed because hepatitis B virus surface antigen (HBsAg) was negative in a widely-used...

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Source: Hepatitis Weekly (1995-07-03)

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