"Immunity to Plasmodium yoelii Infection Elicited by Hybrid Hepatitis B virus Core Particles (HBcAg) Carrying Circumsporozoite Antigen Epitopes."

According to an abstract submitted by the authors to the 95th General Meeting of the American Society for Microbiology, held May 21-25, 1995, in Washington, D.C., "We have previously demonstrated that immunization with hybrid HBcAg particles carrying repeat epitopes of the plasmodial circumsporozoite antigen (CS) can elicit high tittered serum antibody responses against CS and protect mice against P. berghei challenge. To test the protective efficacy of hybrid CS HBcAg particles in a more stringent rodent malaria, we cloned the sequences coding for an immunodominant repeat region epitope of P. yoelii CS in tandem into an internal site of the HBc gene. Hybrid CS HBcAg...

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