"Active Compounds from Saussurea lappa Clarks That Suppress Hepatitis B Virus Surface Antigen Gene Expression in Human Hepatoma Cells."

According to the authors' abstract of an article published in Antiviral Research, "We have examined the antiviral activity of the crude extract prepared from the root of Saussurea lappa Clarks, a Chinese medicinal herb which is widely used for many illneses including cancer. Two active components, costunolide and dehydrocostus lactone, were identified which show strong suppressive effect on the expression of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells, but have little effect on the viability of the cells. Both costunolide and dehydrocostus lactone suppress the HBsAg production by Hep3B cells in a dose-dependent manner with IC₅₀ s of 1.0 and 2.0...

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