DNA-Vaccination/HBV

Murine Humoral Responses Mimic Natural Infection in Humans

Published in Hepatitis Weekly, July 17th, 1995

The injection of plasmid DNA expression vectors in mice induced humoral responses that imitated such responses in humans during the course of natural hepatitis B virus (HBV) infection.

The study involved comparing the fine specificity of the humoral response obtained after DNA-mediated immunization using several plasmid vectors encoding the different HBV envelope proteins, reported Marie-Louis Michel, Institut Pasteur, Paris, France, and colleagues ("DNA-Mediated Immunization to the Hepatitis B Surface Antigen in Mice: Aspects of the Humoral Response Mimic Hepatitis B Viral Infection in Humans," Proceedings of the National Academy of Sciences, June...

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Source: Hepatitis Weekly (1995-07-17)

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