Virology/HCV
"Occurrence of Antibodies Reactive with More Than One Variant of the Putative Envelope Glycoprotein (gp70) Hypervariable Region 1 in Viremic Hepatitis C Virus-Infected Patients."
Published in Hepatitis Weekly, July 24th, 1995
According to the authors' abstract of an article published in Journal of Virology, "The hepatitis C virus (HCV) is a frequent cause of chronic liver disease. A mechanism proposed as being responsible for virus persistence is evasion of the host immune response through a high mutation rate in crucial regions of the viral genome. We have sequenced the hypervariable region 1 (HVR1) of the virus isolated from three serum samples, collected during 18 months of follow-up, from an asymptomatic HCV-infected patient. A synthetic peptide of 27 amino acids, corresponding to the HVR1 sequence found to be predominant in both the second and third samples, was used as the antigen for detection of...
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Source: Hepatitis Weekly (1995-07-24)
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