"Hepatitis A Viruses with Deletions in the 2A Gene Are Infectious in Cultured Cells and Marmosets."

According to the authors' abstract of an article published in Journal of Virology, "The 2A gene of hepatitis A virus (HAV) bears no obvious similarity to the corresponding genes of other picornaviruses and has no known function. In a preliminary effort to gain information about the HAV 2A gene product, we constructed several HAV cDNAs containing deletions of 30 or 45 nucleotides in the predicted central portion of the 2A gene. These deletions did not affect the sites of protein processing, although the rates or efficiencies of polyprotein cleavage at the surrounding cleavage junctions appeared slightly reduced. Transfection of FRhK-4 cells with RNA transcripts of the deleted HAV cDNAs...

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