"Differential Inhibition of Viral Polymerases by Enantiomers of Penciclovir Triphosphate."

According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "The acyclic nucleoside penciclovir (PCV) has activity against herpesviruses such as herpes simplex virus (HSV) and varicella zoster virus (VZV). It is also effective against hepatitis B virus and is well tolerated in patients. When transformed in cells to the triphosphate form, the resultant nucleotide can exist as 2 enantiomers, (S)- and/or (R)-PCVTP. (S)-PCVTP was the only enantiomer found in HSV-1 and VZV infected cells, but about 10% of...

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