Drug Delivery (HBV)
Lipid Prodrugs May Be Useful in Chronic Hepatitis
Published in Hepatitis Weekly, June 10th, 1996
In woodchuck studies, researcher Brent A. Korba et al. found that these phosphatidyl-dideoxyguanosines had enhanced antiviral activity over dideoxyguanosine alone in hepatitis therapy.
A number of nucleosides have been found to inhibit hepatitis B virus (HBV) replication in vitro. Recently lamivudine (3TC) was shown to be effective in chronic hepatitis B in a double-blind, randomized clinical study. After three months of treatment at a dosage of 100 mg/kg/day, all patients exhibited undetectable serum levels of HBV DNA. Serum HBV DNA reappeared...
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Source: Hepatitis Weekly (1996-06-10)
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