Published in Hepatitis Weekly, June 24th, 1996
Three hepatitis B viruses infecting humans, woodchucks, and ground squirrels increase the risk of hepatocellular carcinoma in their respective hosts. The woodchuck hepatitis virus, unlike the two other viruses, induces a rapid carcinogenic process characterized by viral DNA. The highly preferred target of insertional mutagenesis in woodchucks is N-myc2, an intronless N-myc gene.
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