Antisense Technology

Targeted Antisense DNA Blocks HBV Replication

Published in Hepatitis Weekly, July 15th, 1996

Preexposure of cells to targeted complexed antisense DNA can substantially block viral gene expression and viral replication after transfection of hepatitis B virus DNA, according to a report from Japan.

Previous studies have shown a potential application of antisense oligonucleotides in the treatment of viral infections. Investigators have shown that antisense oligonucleotides can be administered to hepatitis B virus (HBV) infected cells to block virus production in a preexisting infection. In addition, researcher Koichi Nakazono and colleagues have shown that antisense oligo DNA can be targeted to HBV infected hepatocytes in vitro, resulting in specific inhibition...

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Source: Hepatitis Weekly (1996-07-15)

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