Therapy (HCV)

Sequence Variation in HCV Related to IFN Response

Published in Hepatitis Weekly, July 22nd, 1996

A high rate of sequence variation in the hypervariable region of hepatitis C virus appears to be related to lowered effectiveness of interferon alpha therapy, according to a report from Korea.

Hepatitis C virus (HCV), like other RNA viruses, exhibits considerable genomic diversity and is capable of spontaneous mutation. Mutations were more frequent in the hypervariable region (HVR) of the HCV gene corresponding to 27 amino acid residues located at the amino terminus of envelope gene 2 and nonstructural gene 1 (E2/NS1). It has been suggested that mutation at HVR of HCV is an adaptive process to escape from the host immune system for continuous propagation.

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Source: Hepatitis Weekly (1996-07-22)

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