Published in Hepatitis Weekly, July 22nd, 1996
Hepatitis C virus (HCV), like other RNA viruses, exhibits considerable genomic diversity and is capable of spontaneous mutation. Mutations were more frequent in the hypervariable region (HVR) of the HCV gene corresponding to 27 amino acid residues located at the amino terminus of envelope gene 2 and nonstructural gene 1 (E2/NS1). It has been suggested that mutation at HVR of HCV is an adaptive process to escape from the host immune system for continuous propagation.
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