Immunology

Plasmid Constructs with HCV Core Protein is Potential Therapy

Published in Hepatitis Weekly, August 5th, 1996

Plasmid constructs expressing hepatitis C virus core protein generate strong cytotoxic T lymphocyte activity and are promising candidates as antiviral agents, according to a multicenter report.

There is an urgent need to develop new antiviral agents which can eradicate persistent HCV infection from the liver. In this regard, direct injection of DNA into animals is a promising method for delivering specific antigens for immunization. This approach has been successfully used to generate protective immunity against influenza virus in mice and chickens, against bovine herpes virus 1 in mice and cattle, and against rabies virus in mice.

"In most cases,...

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Source: Hepatitis Weekly (1996-08-05)

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