Therapy

Prednisolone Useful in Alcohol-Related Hepatitis Disease

Published in Hepatitis Weekly, August 5th, 1996

Corticosteroid treatment is effective in reducing mortality in patients with severe alcoholic hepatitis for at least one year, and could result in delay of liver transplant in responding patients, according to a study from France.

Alcoholic hepatitis is a necrotizing inflammatory lesion of alcoholic liver injury that, in its severe form, is associated with high mortality. Several therapeutic drugs such as propylthiouracil and anabolic steroids, have been evaluated in the treatment of this disease, but none has been shown to decrease mortality.

Randomized trials of corticosteroid therapy in alcoholic hepatitis have been inconclusive.

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Source: Hepatitis Weekly (1996-08-05)

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