Pathogenesis (HBV)

High Mutation Rate in HBc During HBV Clearance

Published in Hepatitis Weekly, August 12th, 1996

Changes in the hepatitis B core gene sequence appear to be rare in the immune tolerant phase of hepatitis B infection but are very high in the immune clearance of chronic infection.

Cross-sectional studies have found that hepatitis B core gene mutations are associated with active liver disease and responsiveness to interferon therapy. In view of the heterogeneity in published sequences, it is not possible to tell whether the differences in sequences observed were true mutations that developed during the course of infection.

In this longitudinal study researcher Hakan Bozkaya and colleagues sought to determine the rate of hepatitis B core gene...

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Source: Hepatitis Weekly (1996-08-12)

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